Aiyuk lines up as SF’s speed vertically and in-space operator. With Purdy’s distribution and McCaffrey pulling attention, Aiyuk can see efficient catches and chunk plays. Seattle’s matchup could yield a strong target share and red-zone looks.

Aiyuk didn’t post big numbers until Week 5 in the prior season; Jennings’ return could push Aiyuk into a slightly reduced target share early, though his big-play ability keeps him in the mix. He remains SF’s big-play threat and a strong weekly fantasy contributor with or without Jennings ramping.

Aiyuk’s knee and Jennings’ calf/contract issues helped Pearsall seize a de facto No. 1 role. Aiyuk’s eventual health will shift the target distribution back, but Pearsall’s emergence adds a broader safe floor for San Francisco’s passing game and fantasy rosters that rely on the 49ers’ aerial attack.

Aiyuk isn't expected to return until Week 6 due to a knee injury, thinning SF's WR corps and pressing Pearsall to step up. His absence heightens the Week 1 urgency for MVS and Pearsall and reshapes early-season target dynamics for SF's aerial attack.

Aiyuk’s health and status loom large; his absence magnifies Pearsall’s burden and could test SF’s ability to maintain an elite offense early. His return will re-balance the WR corps and raise SF’s ceiling.